Antiviral agents derived from novel 1-adamantyl singlet nitrenes.
Identifieur interne : 001D62 ( Main/Exploration ); précédent : 001D61; suivant : 001D63Antiviral agents derived from novel 1-adamantyl singlet nitrenes.
Auteurs : Andreas J. Kesel [Allemagne] ; Hans-Christoph Weiss ; Andreas Schönleber ; Craig W. Day ; Dale L. Barnard ; Mervi A. Detorio ; Raymond F. SchinaziSource :
- Antiviral chemistry & chemotherapy [ 2040-2066 ] ; 2012.
Descripteurs français
- KwdFr :
- Amantadine (analogues et dérivés), Amantadine (pharmacologie), Antiviraux (), Antiviraux (pharmacologie), Cellules cultivées, Cristallographie aux rayons X, Grippe humaine (traitement médicamenteux), Humains, Imines (), Imines (pharmacologie), Infections à respirovirus (traitement médicamenteux), Modèles moléculaires, Syndrome respiratoire aigu sévère (traitement médicamenteux), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), Virus de la grippe A (), Virus du SRAS (), Virus influenza B (), Virus parainfluenza humain de type 3 ().
- MESH :
- analogues et dérivés : Amantadine.
- pharmacologie : Amantadine, Antiviraux, Imines.
- traitement médicamenteux : Grippe humaine, Infections à respirovirus, Syndrome respiratoire aigu sévère.
- Antiviraux, Cellules cultivées, Cristallographie aux rayons X, Humains, Imines, Modèles moléculaires, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus de la grippe A, Virus du SRAS, Virus influenza B, Virus parainfluenza humain de type 3.
English descriptors
- KwdEn :
- Amantadine (analogs & derivatives), Amantadine (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cells, Cultured, Crystallography, X-Ray, HIV-1 (drug effects), Humans, Imines (chemistry), Imines (pharmacology), Influenza A virus (drug effects), Influenza B virus (drug effects), Influenza, Human (drug therapy), Models, Molecular, Parainfluenza Virus 3, Human (drug effects), Respirovirus Infections (drug therapy), SARS Virus (drug effects), Severe Acute Respiratory Syndrome (drug therapy).
- MESH :
- chemical , analogs & derivatives : Amantadine.
- chemical , chemistry : Antiviral Agents, Imines.
- chemical , pharmacology : Amantadine, Antiviral Agents, Imines.
- drug effects : HIV-1, Influenza A virus, Influenza B virus, Parainfluenza Virus 3, Human, SARS Virus.
- drug therapy : Influenza, Human, Respirovirus Infections, Severe Acute Respiratory Syndrome.
- Cells, Cultured, Crystallography, X-Ray, Humans, Models, Molecular.
Abstract
Amantadine constitutes an interesting, diamond crystal lattice-shaped, antivirally active amine with an inhibitory effect on influenza A viruses causing common 'flu' in humans. Unfortunately, amantadine forfeited most of its therapeutic potential because of resistance development in recent influenza A virus isolates. The antiviral efficacy of amantadine congeners can be chemically modified, resulting in re-constitution, improvement and/or extension of antiviral activities mediated by amino-adamantyls.
DOI: 10.3851/IMP2485
PubMed: 23234699
Affiliations:
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Le document en format XML
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Day</name></author><author><name sortKey="Barnard, Dale L" sort="Barnard, Dale L" uniqKey="Barnard D" first="Dale L" last="Barnard">Dale L. Barnard</name></author><author><name sortKey="Detorio, Mervi A" sort="Detorio, Mervi A" uniqKey="Detorio M" first="Mervi A" last="Detorio">Mervi A. Detorio</name></author><author><name sortKey="Schinazi, Raymond F" sort="Schinazi, Raymond F" uniqKey="Schinazi R" first="Raymond F" last="Schinazi">Raymond F. 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Unfortunately, amantadine forfeited most of its therapeutic potential because of resistance development in recent influenza A virus isolates. The antiviral efficacy of amantadine congeners can be chemically modified, resulting in re-constitution, improvement and/or extension of antiviral activities mediated by amino-adamantyls.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><noCountry><name sortKey="Barnard, Dale L" sort="Barnard, Dale L" uniqKey="Barnard D" first="Dale L" last="Barnard">Dale L. Barnard</name><name sortKey="Day, Craig W" sort="Day, Craig W" uniqKey="Day C" first="Craig W" last="Day">Craig W. Day</name><name sortKey="Detorio, Mervi A" sort="Detorio, Mervi A" uniqKey="Detorio M" first="Mervi A" last="Detorio">Mervi A. Detorio</name><name sortKey="Schinazi, Raymond F" sort="Schinazi, Raymond F" uniqKey="Schinazi R" first="Raymond F" last="Schinazi">Raymond F. Schinazi</name><name sortKey="Schonleber, Andreas" sort="Schonleber, Andreas" uniqKey="Schonleber A" first="Andreas" last="Schönleber">Andreas Schönleber</name><name sortKey="Weiss, Hans Christoph" sort="Weiss, Hans Christoph" uniqKey="Weiss H" first="Hans-Christoph" last="Weiss">Hans-Christoph Weiss</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Kesel, Andreas J" sort="Kesel, Andreas J" uniqKey="Kesel A" first="Andreas J" last="Kesel">Andreas J. Kesel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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